Research & Initiatives
Here are some past and current projects. Don’t hesitate to reach out if you want to talk more!
1. Take the Reins: The effects of nutrient timing on cancer-related fatigue (TTR). We will be looking closely at both what and when people eat to see if these factors contribute to people's energy levels. Specifically, we will evaluate whether a time-restricted eating pattern vs. an unrestricted eating pattern will affect perceived energy levels.
You are eligible if:
-You have a diagnosis of a blood cancer (lymphoma, leukemia, multiple myeloma)
-You are 2 months-2 years post-treatment
-You have been living with mild-severe fatigue
Full description of the study: https://clinicaltrials.gov/study/NCT06482515
If you are interested in learning more, contact Carin Clingan, MS, CNS, LDN, lead coordinator, at carin.clingan@umaryland.edu
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2. Relationships between nutrient composition, timing, and physiological responsiveness (ADRIAN). We are recruiting people living with prostate cancer or metastatic breast cancer on hormone therapy. Everyone meets with a nutritionist, and some people are asked to eat within a 10-hour eating window. We ask that you come in once at the beginning of the study and once at the end for assessments including body weight and composition, blood sugar regulation, blood pressure laying down vs. standing up, and others.
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https://clinicaltrials.gov/study/NCT05968144
Status: Closed to recruitment. Data collection and analysis underway.
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3. Leveraging technology to address POST-treatment Health Outcomes of Cancer survivors (POSTHOC): We partnered with Charles River Analytics to build a digital version of the Survivorship Care Plan. We are testing the effects of the digital vs. traditional paper-based version of the Survivorship Care Plan on global symptom burden in the early post-treatment phase of survivorship.
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https://clinicaltrials.gov/ct2/show/NCT05499663
Status: Closed to recruitment. Data collection and analysis underway.
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4. Diet and Nutrition in Cancer (DANICA): Almost all patients who undergoes chemotherapy for cancer experiences cancer-related fatigue. We hypothesized that the components of the Mediterranean Diet, such as high protein, anti-inflammatory properties, antioxidant properties, would prevent fatigue. We investigated the effects of a Mediterranean Diet on cancer-related fatigue and underlying mitochondrial mechanisms. We found that the Mediterranean Diet led to less fatigue during chemotherapy for people who did not follow a Mediterranean Diet before the study. We also found that mitochondrial dysfunction was associated with cancer-related fatigue.
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https://clinicaltrials.gov/ct2/show/NCT04534738
Status: Closed to accrual, results published
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5. Time-restricted eating (TRE): Time-restricted eating is a practice in which people eat all their food within specific window during the day, for example 10-hours. We found that cancer survivors are willing and able to adhere to the TRE pattern. People felt less fatigue at the end of the study vs. before.
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https://clinicaltrials.gov/ct2/show/NCT04243512
Status: Closed to accrual, results published
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6. Fatigue REDuction After Cancer (FREDA): We think that this fatigue might be related to impaired circadian rhythm, or disruption of a person’s internal body clock. We hypothesize that time-restricted eating can help entrain circadian rhythm and reduce persistent fatigue.
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https://clinicaltrials.gov/ct2/show/NCT05256888
Status: Closed to recruitment. Data collection and analysis underway.
